SS-31, also known as Elamipretide, is a mitochondria-targeting peptide that has been developed to protect and repair mitochondria by reducing oxidative stress and improving energy production. It binds to cardiolipin, a lipid unique to the inner mitochondrial membrane, and helps stabilize mitochondrial membranes. By doing so, SS-31 enhances mitochondrial function, improves ATP production, and protects against cellular damage caused by oxidative stress. SS-31 is particularly beneficial in conditions where mitochondrial dysfunction is central, such as neurodegenerative diseases, cardiovascular diseases, and muscle disorders.
SS-31 was developed by Stealth Biotherapeutics in the early 2000s as part of research into compounds that could specifically target and protect mitochondria. Cardiolipin, a mitochondrial lipid that plays a vital role in maintaining mitochondrial structure and energy metabolism, was identified as a key target. SS-31’s ability to selectively bind cardiolipin and protect against oxidative damage led to its investigation in various diseases involving mitochondrial dysfunction, including heart failure, ischemia-reperfusion injuries, and muscular and neurodegenerative conditions. It has since been the subject of multiple clinical trials, showing promise in improving mitochondrial function and overall cellular health.
SKU: MAF/SS31/50/SV/KIT
