FOX04-DRI (FoxO4-D-Retro-Inverso) is a synthetic peptide designed to inhibit interactions between the FOXO4 protein and p53, a key regulator of cell apoptosis. This peptide selectively induces senescent cell death, a process known as “senolysis,” which has the potential to promote cellular rejuvenation and reduce age-related dysfunction. By targeting senescent cells, FOX04-DRI aims to improve tissue function and longevity, potentially offering a novel therapeutic approach for age-related diseases.
FOX04-DRI was developed in the context of research into cellular senescence and aging. Scientists discovered that the FOXO4 protein plays a crucial role in the survival of senescent cells, which accumulate in tissues over time and contribute to aging and chronic disease. By blocking FOXO4’s interaction with the p53 protein, researchers were able to selectively eliminate these senescent cells, leading to improvements in health markers in animal studies. The development of FOX04-DRI is a significant step forward in the field of senolytics, a class of drugs aimed at clearing senescent cells to improve health span and potentially lifespan.
SKU: MAF/FOXDRI/5/10/SV/KIT
