AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a synthetic peptide and AMP analog that activates AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis. By stimulating AMPK, AICAR mimics the effects of exercise at the cellular level, making it a promising compound for metabolic health, endurance enhancement, and fat loss.
Initially developed in the 1980s for use in treating metabolic conditions and cardiac ischemia, AICAR gained prominence when studies revealed its capacity to enhance endurance and metabolic function in both animals and humans. It is often used in research and performance medicine for its effects on energy metabolism.
Fat Loss and Metabolic Health:
Purpose: Enhances fat oxidation and reduces adipose tissue accumulation.
Benefits: Improves body composition and insulin sensitivity.
Dosage Example: 25-50 mg subcutaneously or intramuscularly daily for 4-6 weeks.
Endurance and Stamina Enhancement:
Purpose: Mimics exercise-induced pathways to increase mitochondrial biogenesis.
Benefits: Enhances aerobic capacity and energy production.
Dosage Example: 50 mg subcutaneously 30 minutes prior to endurance training, 3-5x per week.
Improved Insulin Sensitivity:
Purpose: Activates AMPK to facilitate glucose uptake and lower insulin resistance.
Benefits: Aids in the management of metabolic syndrome and prediabetes.
Dosage Example: 25 mg
subcutaneously daily for 6-8 weeks.
Support in Type 2 Diabetes Management:
Purpose: Helps regulate blood glucose levels in conjunction with lifestyle interventions.
Benefits: Promotes better glycemic control.
Dosage Example: 25-50 mg subcutaneously or IM daily, under clinical supervision.
Muscle Preservation During Caloric Deficit:
Purpose: Maintains lean muscle mass during weight loss.
Benefits: Reduces catabolism and supports recovery.
Dosage Example: 25-50 mg daily during dieting phases for up to 6 weeks.
Dosage and Administration:
Reconstitution:
Reconstitute 50 mg of AICAR with 2 mL of bacteriostatic water for a concentration of 25 mg/mL.
General Dosage Range:
Method of Administration:
Subcutaneous (Sub-Q) Injection: Preferred for daily metabolic support or fat loss.
Duration of Use:
SKU: MAF/AICAR50/SV/KIT
